MovDisordV3, Main, Exploration, bibRecord, 004E17

Acute and chronic effects of clozapine in essential tremor

Identifieur interne : 004E17 ( Main/Exploration ); précédent : 004E16; suivant : 004E18

Acute and chronic effects of clozapine in essential tremor

Auteurs : Roberto Ceravolo [Italie] ; Stefania Salvetti [Italie] ; Paola Piccini [Royaume-Uni] ; Claudio Lucetti [Italie] ; Gianna Gambaccini [Italie] ; Ubaldo Bonuccelli [Italie]

Source :

Movement Disorders [ 0885-3185 ] ; 1999-05.

RBID : ISTEX:1D26A034CBFC106C2766EAA83ACA73DAAAA01126

Descripteurs français

Pascal (Inist)
- Chimiothérapie, Clozapine, Court terme, Dibenzodiazépine, Essai croisé, Essentiel, Etude double insu, Homme, Long terme, Mécanisme action, Neuroleptique, Psychotrope, Randomisation, Réfractaire, Sédation, Toxicité, Traitement, Tremblement.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Acute and chronic administration, Antipsychotic Agents (therapeutic use), Chemotherapy, Clozapine, Clozapine (therapeutic use), Cross-Over Studies, Crossover study, Dose-Response Relationship, Drug, Double blind study, Double-Blind Method, Essential, Essential tremor, Female, Human, Humans, Long term, Male, Mechanism of action, Middle Aged, Neuroleptic, Psychotropic, Randomization, Refractory, Sedation, Short term, Toxicity, Treatment, Treatment Outcome, Tremor, Tremor (drug therapy).
MESH :
- chemical , therapeutic use : Antipsychotic Agents, Clozapine.
- drug therapy : Tremor.
- Cross-Over Studies, Dose-Response Relationship, Drug, Double-Blind Method, Female, Humans, Male, Middle Aged, Treatment Outcome.

Abstract

Patients with essential tremor (ET) may not respond to commonly used drugs. Clozapine, an atypical neuroleptic drug, has been reported to improve postural Parkinson's disease tremor clinically resembling ET. The effects of a single dose of 12.5 mg clozapine and placebo were evaluated in a randomized, double‐blind, crossover study in 15 drug‐resistant patients with ET. Patient responders with more than 50% improvement after a single dose of clozapine subsequently received the drug (39 ± 9 mg up to 50 mg) unblinded for a period of 15.8 ± 7.7 months. Tremor was effectively reduced by a single dose of clozapine in 13 of 15 patients (p <0.01). Sedation was the only side effect reported during the clozapine test; however, the time course of sedation and of the antitremor effect were not coincident. A significant reduction of tremor was reported with chronic clozapine treatment (p <0.01) with no tolerance to drug antitremor effect, whereas sedation markedly decreased after 6–7 weeks of therapy. No clozapine‐induced hematologic side effects were observed in our cohort of patients during long‐term treatment. Our results suggest that in selected drug‐resistant ET cases, clozapine should be considered before resorting to neurosurgical options.

Url:

https://api.istex.fr/document/1D26A034CBFC106C2766EAA83ACA73DAAAA01126/fulltext/pdf

DOI: 10.1002/1531-8257(199905)14:3<468::AID-MDS1013>3.0.CO;2-M

Affiliations:

Le document en format XML

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<author><name sortKey="Salvetti, Stefania" sort="Salvetti, Stefania" uniqKey="Salvetti S" first="Stefania" last="Salvetti">Stefania Salvetti</name>
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<author><name sortKey="Piccini, Paola" sort="Piccini, Paola" uniqKey="Piccini P" first="Paola" last="Piccini">Paola Piccini</name>
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<author><name sortKey="Lucetti, Claudio" sort="Lucetti, Claudio" uniqKey="Lucetti C" first="Claudio" last="Lucetti">Claudio Lucetti</name>
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<author><name sortKey="Gambaccini, Gianna" sort="Gambaccini, Gianna" uniqKey="Gambaccini G" first="Gianna" last="Gambaccini">Gianna Gambaccini</name>
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<term>Antipsychotic Agents (therapeutic use)</term>
<term>Chemotherapy</term>
<term>Clozapine</term>
<term>Clozapine (therapeutic use)</term>
<term>Cross-Over Studies</term>
<term>Crossover study</term>
<term>Dose-Response Relationship, Drug</term>
<term>Double blind study</term>
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<term>Essential tremor</term>
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<term>Human</term>
<term>Humans</term>
<term>Long term</term>
<term>Male</term>
<term>Mechanism of action</term>
<term>Middle Aged</term>
<term>Neuroleptic</term>
<term>Psychotropic</term>
<term>Randomization</term>
<term>Refractory</term>
<term>Sedation</term>
<term>Short term</term>
<term>Toxicity</term>
<term>Treatment</term>
<term>Treatment Outcome</term>
<term>Tremor</term>
<term>Tremor (drug therapy)</term>
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<term>Dibenzodiazépine</term>
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<term>Etude double insu</term>
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<term>Long terme</term>
<term>Mécanisme action</term>
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<term>Psychotrope</term>
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<term>Réfractaire</term>
<term>Sédation</term>
<term>Toxicité</term>
<term>Traitement</term>
<term>Tremblement</term>
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<front><div type="abstract" xml:lang="fr">Patients with essential tremor (ET) may not respond to commonly used drugs. Clozapine, an atypical neuroleptic drug, has been reported to improve postural Parkinson's disease tremor clinically resembling ET. The effects of a single dose of 12.5 mg clozapine and placebo were evaluated in a randomized, double‐blind, crossover study in 15 drug‐resistant patients with ET. Patient responders with more than 50% improvement after a single dose of clozapine subsequently received the drug (39 ± 9 mg up to 50 mg) unblinded for a period of 15.8 ± 7.7 months. Tremor was effectively reduced by a single dose of clozapine in 13 of 15 patients (p <0.01). Sedation was the only side effect reported during the clozapine test; however, the time course of sedation and of the antitremor effect were not coincident. A significant reduction of tremor was reported with chronic clozapine treatment (p <0.01) with no tolerance to drug antitremor effect, whereas sedation markedly decreased after 6–7 weeks of therapy. No clozapine‐induced hematologic side effects were observed in our cohort of patients during long‐term treatment. Our results suggest that in selected drug‐resistant ET cases, clozapine should be considered before resorting to neurosurgical options.</div>
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Movement Disorders (revue)

Acute and chronic effects of clozapine in essential tremor

Acute and chronic effects of clozapine in essential tremor

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.